By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer agents covers environmentally and occupationally major cancer agents of business origins.
The booklet discusses the structure-activity relationships, metabolism, and environmental importance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and similar aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental value of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and similar compounds. The structure-activity relationships, metabolism, and environmental value of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and comparable compounds thiocarbonyl compounds also are encompassed. The publication extra tackles the structure-activity relationships, metabolism, and environmental importance if fatty acids, detergents, and different surfactants with oncogenic strength. The textual content then appears into the impact of chemical reactivity, molecular geometry, and metabolism on carcinogenic job.
Chemists, geneticists, and people desirous about melanoma examine will locate the e-book precious.
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Extra info for Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms
In the halopropene series a very good correlation between alkylating and mutagenic activities of at least nine compounds has been noted by Eder et al. (70) and by Neudecker et al. (72). In agreement with the expected order of relative chemical reactivity, the mutagenic potency (with and without metabolic activation) of allyl halides follows the order: iodide > bromide > chloride (70). Similarly, the relative order of potencies (without metabolic activation) is: ds-l,3-dichloro- > mms-l,3-dichloro- > 3-chloro-2-methyl- > 2,3-dichloro- > 3-chloro- > 2-chloro- and 1-chloropropene (inactive), consistent with their relative alkylating activity (72).
Perinatal exposures of Swiss ICR mice to 1/32, 1/8, and 1/2 maximum allowable concentrations (MAC) of halothane 2 h/day on days 11, 13, 15, and 17 of gestation and 2 h/day, 3 days/week for 8 weeks post-partum elicited no significant carcinogenic effects.
A possible increase in the incidence of benign mammary tumors was noted (cited in ref. 3). Inadequate number of rats survived long enough to be at risk from late-developing tumors. It is not certain whether the duration of the experiment was sufficiently long (see text). C None None (233) (233) (233) (253) (254) (254) (252) (252) (251) (233) (233) (248-250) (248-250) (172) (247) (68) Reference In addition to the studies listed above, dichloromethane, and bromodichloromethane have been tested in pulmonary adenoma assay and found to have no significant effect (see Table X ) .